Insilico Medicine’s AI-developed drug detects anti-aging signals in human trials, with six aging clocks all showing a reduction in biological age.

According to Bloomberg, the UK has reopened ￡4.25 billion in gilts maturing in 2056, with an issuance yield of 5.8168%—the highest yield paid on a UK government bond since at least the establishment of the UK Debt Management Office in 1998. A source familiar with the matter said the pricing of this transaction was 0.75 basis points higher than the yield on UK gilts maturing in December 2055 with a 4.25% coupon. The offering ultimately drew ￡85 billion in subscriptions, resulting in a 20x oversubscription ratio, and the gilt carries a 5.375% coupon. The joint lead managers for the deal are BofA Securities, Goldman Sachs International, JPMorgan, Santander, and UBS Investment Bank.

According to Bloomberg, SpaceX’s share price has been trading in a narrow range recently, but a new wave of buying may be coming soon as the Nasdaq 100 index will undergo its quarterly rebalance later this month. The key factors include a little-known rule in the construction of this tech-heavy benchmark and the staged lock-up period arrangements for shareholders of Elon Musk’s satellite and space exploration company. These elements have limited the number of SpaceX shares available for trading in the current market.

According to HTX market data, MARSCOIN, a meme coin in the BNB Chain ecosystem, has halved its market capitalization from its peak, briefly dropping below $130 million, with a 24-hour decline of 22.34%.

According to TradingBeats' monitoring, the implied probability that the CLARITY Act will be signed into law this year has dropped to 15.5%. Among whales active across markets in this prediction market segment, only two traders who have long been active on both Polymarket and Hyperliquid still hold their previously established "Yes" positions, and have not exited as odds have fallen. TwoEyes and Geminae.Columbae currently hold a combined ~254,600 "Yes" contracts, with a position value of roughly $39,500, and a combined unrealized loss of ~$11,800. The average entry cost for both corresponds to a roughly 20% probability of the Act being signed into law, meaning the market price is now significantly lower than their entry level. Of the two, TwoEyes holds ~195,500 "Yes" contracts, with an average entry cost corresponding to a 20.2% probability, and an unrealized loss of ~$9,197; Geminae.Columbae holds ~59,200 contracts, with an entry cost probability of 19.94%, and an unrealized loss of ~$2,628. The two still hold large exposure to crypto assets on the other side. Data from Hyperliquid shows their combined nominal size of current crypto long positions is ~$19.92 million. TwoEyes holds a ~$1.606 million BTC long position, plus a ~$348,000 crude oil short position. Geminae.Columbae, meanwhile, holds long positions in BTC, ZEC, LINK, and HYPE, totaling ~$18.317 million.

According to market data from BIT (bit.com), Oracle's US stock rose 4.49% in pre-market trading, currently trading at $166.91.

According to GMGN data, the stock-linked meme token "build" paired with BNC4 on BNB Chain exceeded $50 million in market capitalization and recorded $20 million in trading volume within six hours of its launch. The "build" token is paired with tokenized U.S. stock BNC (CEA Industries, a BNB treasury company) as its liquidity base, with liquidity provided via the build/BNC4 trading pair. BlockBeats Note: Meme coin trading is highly volatile, largely driven by market sentiment and conceptual hype, with no actual value or use cases. Investors should exercise caution regarding associated risks.