DeepMind Develops AI Map of the Human Genome, Enabling Direct Lookup of 9 Billion DNA Variations.
50 minutes ago
Beating AI News reports that Google DeepMind has launched the AlphaGenome Atlas, a searchable database precomputing all ~9 billion possible single-letter DNA variations in the human genome. The entire dataset is around 1 petabyte (PB), over 30 times larger than the AlphaFold Database. With the human genome containing roughly 3 billion DNA letters, each position can be replaced by 3 other bases, leading to the ~9 billion single-letter variations. Previously, researchers had to analyze variations individually using AlphaGenome; now they can directly retrieve results from the Atlas, avoiding repeated model runs. The Atlas also provides an AVI score for each variation, integrating predictions from AlphaGenome and AlphaMissense to help researchers prioritize variants most likely to have functional impacts. It covers both the ~2% protein-coding regions and the remaining 98% non-coding regions, which are harder to study. Multiple research teams have already used the tool to identify previously overlooked rare disease-related variations, with experiments confirming one such variant causes abnormal RNA splicing.
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