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Alphabet’s AI drug discovery subsidiary Isomorphic Labs is in talks for a new round of financing worth approximately $5 billion, with a corresponding valuation of around $50 billion. People familiar with the matter said the financing has not been finalized yet, and details may change. Founded in 2021 by Demis Hassabis as a spin-off from Google DeepMind, the London-based firm’s core business leverages AI technologies including AlphaFold to accelerate drug design and discovery. It just completed a $2.1 billion Series B funding round in May this year, led by Thrive Capital with participation from Alphabet and other investors. Bloomberg previously reported in October that the company was in early-stage financing discussions, with a valuation range of $40 billion to $50 billion. Currently, Isomorphic Labs remains in the pre-clinical stage, and Hassabis has stated that the firm expects to enter its first clinical trial by the end of 2026.

According to an official announcement from Japanese cryptocurrency exchange platform Zaif, its email distribution service contractor Arara Co. suffered unauthorized server access, confirming that customer email addresses registered in the service have been leaked. Per Arara’s report, the deduplicated number of leaked emails totals 380,536, containing only email addresses—no personal information such as names or email bodies. Zaif stated that only emails were registered for this service, with no names, addresses, phone numbers, transaction details, or passwords recorded, and no breach of its own systems has been confirmed. The leaked data does not include authentication information like passwords, so accounts cannot be accessed using only email addresses. As of press time, no secondary damages such as unauthorized logins or asset outflows linked to the incident have been confirmed. Due to Arara’s service suspension, Zaif has temporarily halted all notification email distributions, and advised users to stay vigilant against phishing and fraudulent emails, warning them not to click unfamiliar links or submit authentication information. This is the second report on the leak, following the initial disclosure of a potential data breach on November 2. Relevant details have been reported to the competent authorities.

According to Coinglass data, global crypto liquidations reached $983 million over the past 24 hours, including $401 million in long positions and $582 million in short positions. Bitcoin liquidations hit $398 million, while Ethereum liquidations stood at $243 million. The single largest liquidation order occurred on HTX-ETH-USDT, valued at $37.9991 million.

Russia’s largest stock exchange, Moscow Exchange (MOEX), announced it will open digital currency trading services to financial market participants starting December 1, 2026. This move marks the official launch of Russia’s first organized digital currency market. According to an official announcement from MOEX dated November 2, the trading will be conducted using the existing technical infrastructure of its stock market and integrated into the unified clearing system of the National Clearing Centre. Trading hours will align with the stock market, running from 06:50 to 23:50 Moscow time daily. The first batch of supported assets includes Bitcoin (BTC), Ethereum (ETH), and Tether (USDT), with both address-free (anonymous order book) and address-based trading modes available. The market will also offer same-day settlement (TOD), next-day settlement (TOM), and swap tools for liquidity management. The exchange noted that it will gradually expand its trading products to include more international and Russian domestic digital assets in the future. The service will initially operate as a pilot program, with market participants connecting gradually based on system readiness.

According to The Block, U.S. crypto lobbying group Digital Chamber has labeled the victory of Democrat Sherrod Brown in Ohio’s Senate election as the “most consequential unfavorable result for the crypto industry.” The group noted that Brown’s policy priorities on financial stability, consumer protection, bank regulation, and combating illicit finance could influence the Democratic Party’s overall stance and policy direction on crypto assets. Brown previously served as chair of the Senate Banking Committee, taking a cautious approach to digital asset legislation and regulation while stressing risks related to illicit finance. During the recent midterm elections, crypto-focused political action committees (PACs) poured substantial funds into efforts to block his return to the Senate, but were unsuccessful. Digital Chamber’s latest comments further underscore the crypto industry’s concerns over a tightening regulatory environment following shifts in Congress’s makeup.

The whale who went long $147M in #oil is starting to give up, with total losses of $15.3M! He closed his 587,250 $CL ($51.87M) long, losing $5.83M. He still holds a long on 1M $BRENTOIL ($93.7M), with a $9.45M unrealized loss. Liquidation price: $82.4.